Guidelines for RQ-PCR MRD
EuroMRD's interpretation guidelines define how RQ-PCR-based MRD data should be categorized and reported. These guidelines are what makes an 'MRD negative' or 'MRD positive' result mean the same thing regardless of which center generated it. The current guidelines were most recently updated in 2024, building on the original 2007 framework.
The EuroMRD guidelines for interpretation of real-time quantitative (RQ) PCR data for analysis of minimal residual disease based on Ig/TCR gene rearrangements can be downloaded below:
Updated guidelines 2024: Van der Velden et al., Leukemia 2024;38:1315-22: Analysis of measurable residual disease by IG/TR gene rearrangements: quality assurance and updated EuroMRD guidelines